necessarily, of necessity, perforce, urgently, indispensably

a kind of dry medicine poured into eye wound

absolutely, certainly, necessary, needful, surely, definitely, of course

certainly, of course, necessarily, without fail

possess, have

important talks, necessary matters

there is something rotten in the state of Denmark

toilet

privy, latrine, lavatory, toilet

must, necessary

constantly refuse

No No, never, of course not (for emphasis on denial)

it is of no consequence, no matter, nevermind

it is of no consequence, no matter, there is no harm in it, never mind

(it is) of no great consequence, (there is) little harm in it

it is of no consequence, no matter, there is no harm in it, never mind